Working Model: onsite (five days a week)
Working days: Monday through Friday
Working hours (e.g. 8 AM to 4 PM PT, 9 AM to 5 PM, etc.): Standard 8 hours
Position Summary
We are seeking a highly motivated and skilled Scientist to join our Biochemical and Cellular Pharmacology Department. This hands-on, laboratory-based role focuses on the development and execution of induced proximity-based assays crucial for the discovery and validation of Client therapeutic compounds. The successful candidate will work at the heart of a multi-disciplinary environment, translating experimental data into actionable insights for our drug discovery programs.
In this role, the candidate will have the unique opportunity to pioneer new induced-proximity approaches and help shape the scientific direction of early-stage drug-discovery programs.
Key Responsibilities
Assay Development: Design and develop biochemical and cell-based assays for quantitative measurement of protein–protein and protein–small molecule interactions.
Screening & Validation: Conduct routine screening and deep-dive validation studies to support lead identification and optimization.
Data Analysis: Perform rigorous analysis of complex data sets, ensuring high quality and reproducibility.
Cross-Functional Collaboration: Partner effectively with colleagues in Pharmacology, Protein Science, Medicinal Chemistry and Research Biology.
Communication: Prepare technical reports and present findings clearly during multi-disciplinary project team meetings.
Education & Experience
Degree: B.S. or M.S. in Biochemistry, Biophysics, Cellular/Molecular Biology, or a related scientific discipline.
Experience: 1–3 years of hands-on laboratory experience within an academic, biotechnology, or pharmaceutical industry setting.
Mandatory Skiils Requirements
Demonstrated experience designing, developing, validating, and executing cellular and biochemical assays, supported by a strong theoretical and practical understanding of biochemistry and biophysics relevant to complex protein systems.
Direct experience with induced proximity assays and modalities (molecular glues, bivalent degraders, ternary complexes and multicomponent binding systems).
Proficiency with data analysis methods and specialized software. Ability to move beyond default vendor fits and analyze complex system behavior using Prism, Python, R or comparable tools.
Proven ability to critically analyze and interpret complex data sets, troubleshoot experimental hurdles, and a proactive interest in adopting new technologies.
Preferred Technical Skills (Advantageous)
Experience with protein biochemistry, recombinant protein expression and molecular biology methods (e.g. western blot, cell culture, cell growth assays).
Experience with nanoBRET, nanoBiT, TR-FRET, BRET as well as imaging-based approaches.
Familiarity with automated or semi-automated laboratory instrumentation (e.g., liquid handlers, plate washers).
Ability to thrive in a fast-paced, dynamic environment and remain productive through shifting priorities or project changes.
Proven ability to work effectively as part of a high-functioning, multi-disciplinary team.
A proactive approach to troubleshooting and a keen interest in learning new technologies as project needs evolve.
Nesco Resource offers a comprehensive benefits package for our associates, which includes a MEC (Minimum Essential Coverage) plan that encompasses Medical, Vision, Dental, 401K, and EAP (Employee Assistance Program) services.
Nesco Resource provides equal employment opportunities to all employees and applicants for employment and prohibits discrimination and harassment of any type without regard to race, color, religion, age, sex, national origin, disability status, genetics, protected veteran status, sexual orientation, gender identity or expression, or any other characteristic protected by federal, state, or local laws.
